The Pacific Highway is closed following a head-on crash near Grafton shortly before 1am.
Emergency services were called to a section of the highway about six kilometres south of Grafton following the collision between a northbound van and a southbound B-double truck.
The male driver of the van sustained serious injuries and was taken to Coffs Harbour Hospital, while the male driver of the truck was taken to Grafton Hospital for the treatment of minor injuries.
There were no passengers in either vehicle and the ages of the drivers are not yet known.
Second accident near Clybucca
Just after 1.30am emergency services were called to another section of the Pacific Highway, near Clybucca, following a head-on collision between a southbound car and a northbound campervan.
The driver of the car, a man in his 70s, has been taken to Port Macquarie Hospital with serious injuries. There were no passengers in the car.
The two men travelling in the campervan, both aged in their 20s, were also injured. The passenger sustained serious injuries to his back, while the driver suffered arm and leg injuries. Both have been taken to Coffs Harbour Hospital.
The Pacific Highway remains closed in both directions at each of the crash sites; diversions are in place.
Motorists are encouraged to visit www.livetraffic.com for the latest updates.
