The Easter traffic got off to a bad start after a truck and car collided head-on on the Pacific Highway at Devils Pulpit, about 20km south of Woodburn, around midday yesterday.
Police, emergency services and the Westpac Life Saver Rescue Helicopter attended the accident and the highway was closed in both directions for a number of hours.
The male driver of the motor vehicle was trapped and had to be released by emergency services.
He was taken to Gold Coast Hospital via helicopter where he is believed to be in a serious condition with multiple injuries.
The driver of the truck was taken to Lismore Base Hospital for mandatory blood and urine testing.
Police from Richmond LAC and Ballina Crash Investigation Unit are continuing to investigate.