Brittany Blissett, from Wyan near Casino, was last seen by family members on Friday.
She has not been heard from or seen since she failed to turn up for classes at Casino High School.
Richmond Local Area Command duty officer, Inspector Mick Dempsey, said investigators sought any information on the teenager’s whereabouts, or any information on events leading up to her disappearance.
‘Obviously her parents and family are deeply concerned but we think she may be in Lismore somewhere,’ Insp Dempsey said.
‘Hopefully someone might’ve seen her or can confirm that she is here, and may be able to ask her to return home or at least contact her parents.’
Miss Blissett is reported to be about 160cm tall with an athletic build. She has a lip ring on the right side of her lower lip.
‘Police believe she may be staying in Lismore so please keep a look out for this young girl and if you do see her or know where she is, please contact your local police station or Crime Stoppers.’
Lismore detectives can be contacted on 6626 0599, and any information given to Crime Stoppers can be supplied anonymously, 1800 333 000.