The woman, Rosemary Armstrong-Douglas (pictured), aged in her late 40s, was last seen about 10am today (Saturday 7 September) in the town’s main street.
Police and family hold grave concerns for her welfare due to a medical condition that requires treatment.
She is described as being of Caucasian appearance, about 175cm tall, with long straight black hair and of a thin build.
She was last seen wearing a black-coloured top and dark blue pants and may be driving a white Subaru station wagon, bearing registration plates BP73WT.
Officers have also been told she may frequent the Mount Jerusalem National Park as well as beach areas on the North Coast.
Anyone who may know the whereabouts of the missing person or has information that could assistance investigators is urged to contact Crime Stoppers on 1800 333 000.
Police are urging anyone with information about this incident to call Crime Stoppers on 1800 333 000 or use the Crime Stoppers online reporting page: https://www1.police.nsw.gov.au/.