A 55-year-old woman died after a two-vehicle crash late on Friday morning on the Bangalow Road at Howards Grass, about 4km north of Lismore.
The woman, a front-seat passenger in the northbound vehicle, sustained critical injuries in the accident around 11am and died at the scene.
The drivers, both men, were taken to Lismore Base Hospital with non life-threatening injuries. They have both undergone mandatory blood and urine testing.
The road was closed for several hours while officers from the Crash Investigation Unit examine the scene.
Police are urging anyone with information in relation to this incident to call Crime Stoppers on 1800 333 000.